We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product.
- Authors
Shyp, Viktoriya; Tankov, Stoyan; Ermakov, Andrey; Kudrin, Pavel; English, Brian P; Ehrenberg, Måns; Tenson, Tanel; Elf, Johan; Hauryliuk, Vasili
- Abstract
During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regulation of an enzyme by its product. Positive allosteric regulation therefore constitutes a new mechanism of enzyme activation. By integrating the output of individual RelA molecules and ppGpp degradation pathways, this regulatory circuit contributes to a fast and coordinated transition to stringency.
- Publication
EMBO reports, 2012, Vol 13, Issue 9, p835
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2012.106