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- Title
A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis.
- Authors
Taniue, Kenzui; Oda, Takeaki; Hayashi, Tomoatsu; Okuno, Masumi; Akiyama, Tetsu
- Abstract
Tumour cells are known to be dependent on, or 'addicted to', not only oncogenes, but also some non-oncogenes. However, the mechanisms by which tumour cells are addicted to these genes have not been fully explained. Here, we show that overexpression of a member of the ETS family, EHF, is required for the survival of colon tumour cells that contain wild-type p53. We found that EHF directly activates the transcription of RUVBL1, an ATPase associated with chromatin-remodelling complexes. RUVBL1 blocks p53-mediated apoptosis by repressing the expression of p53 and its target genes. Moreover, we found that RUVBL1 represses p53 transcription by binding to the p53 promoter, interfering with RNF20/hBRE1-mediated histone H2B monoubiquitination and promoting PAF1-mediated histone H3K9 trimethylation. These results indicate that EHF-mediated RUVBL1 expression allows colon tumour cells to avoid p53-mediated apoptosis. Thus, EHF and RUVBL1 might be promising molecular targets for the treatment of colon tumours.
- Publication
EMBO reports, 2011, Vol 12, Issue 7, p682
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2011.81