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- Title
APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.
- Authors
Landry, Sébastien; Narvaiza, Iñigo; Linfesty, Daniel C; Weitzman, Matthew D
- Abstract
Human apolipoprotein-B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) proteins constitute a family of cytidine deaminases that mediate restriction of retroviruses, endogenous retro-elements and DNA viruses. It is well established that these enzymes are potent mutators of viral DNA, but it is unclear whether their editing activity is a threat to the integrity of the cellular genome. We show that expression of APOBEC3A can lead to induction of DNA breaks and activation of damage responses in a deaminase-dependent manner. Consistent with these observations, APOBEC3A expression induces cell-cycle arrest. These results indicate that cellular DNA is vulnerable to APOBEC3 activity and deregulated expression of APOBEC3A could threaten genomic integrity.
- Publication
EMBO reports, 2011, Vol 12, Issue 5, p444
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2011.46