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- Title
The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.
- Authors
Hackmann, Alexandra; Gross, Thomas; Baierlein, Claudia; Krebber, Heike
- Abstract
The nuclear export of large ribonucleoparticles is complex and requires specific transport factors. Messenger RNAs are exported through the RNA-binding protein Npl3 and the interacting export receptor Mex67. Export of large ribosomal subunits also requires Mex67; however, in this case, Mex67 binds directly to the 5S ribosomal RNA (rRNA) and does not require the Npl3 adaptor. Here, we have discovered a new function of Npl3 in mediating the export of pre-60S ribosomal subunit independently of Mex67. Npl3 interacts with the 25S rRNA, ribosomal and ribosome-associated proteins, as well as with the nuclear pore complex. Mutations in NPL3 lead to export defects of the large subunit and genetic interactions with other pre-60S export factors.
- Publication
EMBO reports, 2011, Vol 12, Issue 10, p1024
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2011.155