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- Title
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.
- Authors
Loenarz, Christoph; Coleman, Mathew L; Boleininger, Anna; Schierwater, Bernd; Holland, Peter W H; Ratcliffe, Peter J; Schofield, Christopher J
- Abstract
The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.
- Publication
EMBO reports, 2011, Vol 12, Issue 1, p63
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2010.170