We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest.
- Authors
Kuroha, Kazushige; Akamatsu, Mayuko; Dimitrova, Lyudmila; Ito, Takehiko; Kato, Yuki; Shirahige, Katsuhiko; Inada, Toshifumi
- Abstract
Nascent peptide-dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide-dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1-independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino-acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co-translational protein degradation.
- Publication
EMBO reports, 2010, Vol 11, Issue 12, p956
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2010.169