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- Title
Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.
- Authors
Hoy, Benjamin; Löwer, Martin; Weydig, Christiane; Carra, Gert; Tegtmeyer, Nicole; Geppert, Tim; Schröder, Peter; Sewald, Norbert; Backert, Steffen; Schneider, Gisbert; Wessler, Silja
- Abstract
Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin. E-cadherin shedding disrupts epithelial barrier functions allowing H. pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori.
- Publication
EMBO reports, 2010, Vol 11, Issue 10, p798
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2010.114