We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis.
- Authors
Gebeshuber, Christoph A; Zatloukal, Kurt; Martinez, Javier
- Abstract
Several microRNAs (miRNAs) have recently been described as crucial regulators of epithelial-to-mesenchymal transition (EMT) and metastasis. By comparing the expression profiles of miRNAs, we found upregulation of miR-29a in mesenchymal, metastatic RasXT cells relative to epithelial EpRas cells. Overexpression of miR-29a suppressed the expression of tristetraprolin (TTP), a protein involved in the degradation of messenger RNAs with AU-rich 3'-untranslated regions, and led to EMT and metastasis in cooperation with oncogenic Ras signalling. We also observed enhanced miR-29a and reduced TTP levels in breast cancer patient samples, indicating relevance for human disease. Previously, miR-29 family members were shown to have tumour-suppressive effects in haematopoietic, cholangiocytic and lung tumours. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context.
- Publication
EMBO reports, 2009, Vol 10, Issue 4, p400
- ISSN
1469-3178
- Publication type
Journal Article
- DOI
10.1038/embor.2009.9