We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis.
- Authors
Papusheva, Ekaterina; Heisenberg, Carl-Philipp
- Abstract
Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.
- Publication
The EMBO journal, 2010, Vol 29, Issue 16, p2753
- ISSN
1460-2075
- Publication type
Journal Article
- DOI
10.1038/emboj.2010.182