We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ER stress protects from retinal degeneration.
- Authors
Mendes, César S; Levet, Clémence; Chatelain, Gilles; Dourlen, Pierre; Fouillet, Antoine; Dichtel-Danjoy, Marie-Laure; Gambis, Alexis; Ryoo, Hyung Don; Steller, Hermann; Mollereau, Bertrand
- Abstract
The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with degenerative pathologies, but its role in disease progression is still a matter for debate. Here, we found that mutations in the ER-resident chaperone, neither inactivation nor afterpotential A (NinaA), lead to mild ER stress, protecting photoreceptor neurons from various death stimuli in adult Drosophila. In addition, Drosophila S2 cultured cells, when pre-exposed to mild ER stress, are protected from H(2)O(2), cycloheximide- or ultraviolet-induced cell death. We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death. We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses.
- Publication
The EMBO journal, 2009, Vol 28, Issue 9, p1296
- ISSN
1460-2075
- Publication type
Journal Article
- DOI
10.1038/emboj.2009.76