We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transient receptor potential channels meet phosphoinositides.
- Authors
Nilius, Bernd; Owsianik, Grzegorz; Voets, Thomas
- Abstract
Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca(2+) and Mg(2+) homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of cloning of the first Drosophila TRP channel, a close connection between gating and phosphatidylinositol phosphates (PIPs) was already recognized. In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP-PIP interactions to human physiology and pathophysiology.
- Publication
The EMBO journal, 2008, Vol 27, Issue 21, p2809
- ISSN
1460-2075
- Publication type
Journal Article
- DOI
10.1038/emboj.2008.217