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- Title
Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.
- Authors
Ling Yang; Ying Wu; Huaixin Li; Zhijie Yu; Xin Li; Yong Liu; Xu Lin; Yan Chen
- Abstract
Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings.European Journal of Human Genetics (2008) 16, 759–761; doi:10.1038/ejhg.2008.8; published online 13 February 2008
- Publication
European Journal of Human Genetics, 2008, Vol 16, Issue 6, p759
- ISSN
1018-4813
- Publication type
Academic Journal
- DOI
10.1038/ejhg.2008.8