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- Title
Variation near complement factor I is associated with risk of advanced AMD.
- Authors
Fagerness, Jesen A; Maller, Julian B; Neale, Benjamin M; Reynolds, Robyn C; Daly, Mark J; Seddon, Johanna M
- Abstract
A case-control association study for advanced age-related macular degeneration was conducted to explore several regions of interest identified by linkage. This analysis identified a single nucleotide polymorphism just 3' of complement factor I on chromosome 4 showing significant association (P<10(-7)). Sequencing was performed on coding exons in linkage disequilibrium with the detected association. No obvious functional variation was discovered that could be the proximate cause of the association, suggesting a noncoding regulatory mechanism.
- Publication
European journal of human genetics : EJHG, 2009, Vol 17, Issue 1, p100
- ISSN
1476-5438
- Publication type
Journal Article
- DOI
10.1038/ejhg.2008.140