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- Title
Bioavailability of vitamin D<sub>2</sub> from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial.
- Authors
Urbain, P; Singler, F; Ihorst, G; Biesalski, H-K; Bertz, H
- Abstract
Background/Objectives:Mushrooms contain very little or any vitamin D2 but are abundant in ergosterol, which can be converted into vitamin D2 by ultraviolet (UV) irradiation. Our objective was to investigate the bioavailability of vitamin D2 from vitamin D2-enhanced mushrooms by UV-B in humans, and comparing it with a vitamin D2 supplement.Subjects/Methods:Fresh mushrooms were irradiated with an UV-B dose of 1.5 J/cm2, increasing vitamin D2 content from <1 to 491 μg/100 g and made to an experimental soup. In this 5-week, single-blinded, randomized, placebo-controlled trial, 26 young subjects with serum 25-hydroxyvitamin D (25OHD) 50 nmol/l were randomly assigned into three groups ((a) mushroom, (b) supplement and (c) placebo). They received during winter (a) 28 000 IU (700 μg) vitamin D2 via the experimental soup, or (b) 28 000 IU vitamin D2 via a supplement or (c) placebo, respectively.Results:After 2 weeks, serum 25OHD was significantly higher in the mushroom than in the placebo group (P=0.001). The serum 25OHD concentrations in the mushroom and supplement groups rose significantly and similarly over the study period by 3.9 nmol/l (95% confidence interval (95% CI): 2.9, 4.8) and by 4.7 nmol/l per week (95% CI: 3.8, 5.7), respectively.Conclusions:We are the first to demonstrate in humans that the bioavailability of vitamin D2 from vitamin D2-enhanced button mushrooms via UV-B irradiation was effective in improving vitamin D status and not different to a vitamin D2 supplement. This trial was registered at http://germanctr.de as DRKS00000195.
- Publication
European Journal of Clinical Nutrition, 2011, Vol 65, Issue 8, p965
- ISSN
0954-3007
- Publication type
Academic Journal
- DOI
10.1038/ejcn.2011.53