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- Title
Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects.
- Authors
Ford, H E; Peters, V; Martin, N M; Sleeth, M L; Ghatei, M A; Frost, G S; Bloom, S R
- Abstract
The sweet-taste receptor (T1r2+T1r3) is expressed by enteroendocrine L-cells throughout the gastrointestinal tract. Application of sucralose (a non-calorific, non-metabolisable sweetener) to L-cells in vitro stimulates glucagon-like peptide (GLP)-1 secretion, an effect that is inhibited with co-administration of a T1r2+T1r3 inhibitor. We conducted a randomised, single-blinded, crossover study in eight healthy subjects to investigate whether oral ingestion of sucralose could stimulate L-cell-derived GLP-1 and peptide YY (PYY) release in vivo.
- Publication
European journal of clinical nutrition, 2011, Vol 65, Issue 4, p508
- ISSN
1476-5640
- Publication type
Journal Article
- DOI
10.1038/ejcn.2010.291