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- Title
Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.
- Authors
Bach, Ingolf
- Abstract
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.
- Publication
Cell research, 2012, Vol 22, Issue 11, p1524
- ISSN
1748-7838
- Publication type
Journal Article
- DOI
10.1038/cr.2012.98