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- Title
Indigestible mitochondria cause heartburn.
- Authors
Gottlieb, Roberta A; Linton, Phyllis-Jean
- Abstract
The link between impaired autophagic flux (autophagus interruptus), damaged mitochondria, and myocardial inflammation has been further tightened with the recent paper by Oka and colleagues, in which failure to degrade mitochondrial DNA exacerbated myocardial inflammation in the context of pressure overload. Using mice with cardiac-specific deletion of the lysosomal DNase II that were subjected to aortic banding, Otsu's group showed that mitochondrial DNA accumulated in lysosomes and resulted in TLR9-dependent production of inflammatory cytokines.
- Publication
Cell research, 2012, Vol 22, Issue 11, p1518
- ISSN
1748-7838
- Publication type
Journal Article
- DOI
10.1038/cr.2012.96