We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expanding role of ubiquitination in NF-κB signaling.
- Authors
Siqi Liu; Chen, Zhijian J.
- Abstract
Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.
- Publication
Cell Research, 2011, Vol 21, Issue 1, p6
- ISSN
1001-0602
- Publication type
Academic Journal
- DOI
10.1038/cr.2010.170