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- Title
iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability.
- Authors
Ramos-Mejia, Veronica; Muñoz-Lopez, Martin; Garcia-Perez, Jose L; Menendez, Pablo
- Abstract
Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bona fide iPSCs.
- Publication
Cell research, 2010, Vol 20, Issue 10, p1092
- ISSN
1748-7838
- Publication type
Journal Article
- DOI
10.1038/cr.2010.125