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- Title
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.
- Authors
Shih-Lei Lai; Chien, Andy J.; Moon, Randall T.
- Abstract
Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.Cell Research (2009) 19:532–545. doi: 10.1038/cr.2009.41; published online 14 April 2009
- Publication
Cell Research, 2009, Vol 19, Issue 5, p532
- ISSN
1001-0602
- Publication type
Academic Journal
- DOI
10.1038/cr.2009.41