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Title
The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4.
Authors
Huayu Qi; Duanqing Pei
Abstract
The article focuses on a study regarding an alternative to therapeutic cloning. This study demonstrated the reprogramming process that can be achieved without going through a nuclear transfer into the eggs but by introducing four transcription factors (Oct4, Sox2, cMyc, Klf4) into the fibroblasts. These transcription factors converted somatic cells into embryonic stem cells.