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- Title
Prediction of transporter-mediated drug-drug interactions using endogenous compounds.
- Authors
Fromm, M F
- Abstract
Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug-drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter-mediated drug-drug interactions.
- Publication
Clinical pharmacology and therapeutics, 2012, Vol 92, Issue 5, p546
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2012.145