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- Title
Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study.
- Authors
Weeke, P; Jensen, A; Folke, F; Gislason, G H; Olesen, J B; Andersson, C; Fosbøl, E L; Larsen, J K; Lippert, F K; Nielsen, S L; Gerds, T; Andersen, P K; Kanters, J K; Poulsen, H E; Pehrson, S; Køber, L; Torp-Pedersen, C
- Abstract
Treatment with some types of antidepressants has been associated with sudden cardiac death. It is unknown whether the increased risk is due to a class effect or related to specific antidepressants within drug classes. All patients in Denmark with an out-of-hospital cardiac arrest (OHCA) were identified (2001-2007). Association between treatment with specific antidepressants and OHCA was examined by conditional logistic regression in case-time-control models. We identified 19,110 patients with an OHCA; 2,913 (15.2%) were receiving antidepressant treatment at the time of OHCA, with citalopram being the most frequently used type of antidepressant (50.8%). Tricyclic antidepressants (TCAs; odds ratio (OR) = 1.69, confidence interval (CI): 1.14-2.50) and selective serotonin reuptake inhibitors (SSRIs; OR = 1.21, CI: 1.00-1.47) were both associated with comparable increases in risk of OHCA, whereas no association was found for serotonin-norepinephrine reuptake inhibitors/noradrenergic and specific serotonergic antidepressants (SNRIs/NaSSAs; OR = 1.06, CI: 0.81-1.39). The increased risks were primarily driven by: citalopram (OR = 1.29, CI: 1.02-1.63) and nortriptyline (OR = 5.14, CI: 2.17-12.2). An association between cardiac arrest and antidepressant use could be documented in both the SSRI and TCA classes of drugs.
- Publication
Clinical pharmacology and therapeutics, 2012, Vol 92, Issue 1, p72
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2011.368