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- Title
Pharmacogenetics: from bench to byte--an update of guidelines.
- Authors
Swen, J J; Nijenhuis, M; de Boer, A; Grandia, L; Maitland-van der Zee, A H; Mulder, H; Rongen, G A P J M; van Schaik, R H N; Schalekamp, T; Touw, D J; van der Weide, J; Wilffert, B; Deneer, V H M; Guchelaar, H-J
- Abstract
Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).
- Publication
Clinical pharmacology and therapeutics, 2011, Vol 89, Issue 5, p662
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2011.34