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- Title
The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.
- Authors
Pirmohamed, M; Aithal, G P; Behr, E; Daly, A; Roden, D
- Abstract
The ability to predict the risk for serious drug-induced adverse reactions first requires a large patient database for characterization and validation of genetic markers. The Phenotype Standardization Project (PSP) was initiated to standardize phenotypic definitions, thereby facilitating much-needed recruitment without sacrificing the reliability of patient classification. Three phenotypes have been considered in this initial phase: drug-induced liver injury, drug-induced skin injury, and drug-induced torsade de pointes.
- Publication
Clinical pharmacology and therapeutics, 2011, Vol 89, Issue 6, p784
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2011.30