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- Title
Ketamine as a novel antidepressant: from synapse to behavior.
- Authors
Murrough, J W
- Abstract
Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.
- Publication
Clinical pharmacology and therapeutics, 2012, Vol 91, Issue 2, p303
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2011.244