We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Model-based meta-analysis for comparative efficacy and safety: application in drug development and beyond.
- Authors
Mandema, J W; Gibbs, M; Boyd, R A; Wada, D R; Pfister, M
- Abstract
High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient drug development process. New compounds need to bring value to patients by being safe, efficacious, and cost-effective as compared with existing treatment options. Model-based meta-analysis (MBMA) facilitates integration and utilization of summary-level efficacy and safety data, providing a quantitative framework for comparative efficacy and safety assessment. This Commentary discusses the application and limitations of MBMA in drug development.
- Publication
Clinical pharmacology and therapeutics, 2011, Vol 90, Issue 6, p766
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2011.242