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- Title
Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy.
- Authors
Lerman, C; Jepson, C; Wileyto, E P; Patterson, F; Schnoll, R; Mroziewicz, M; Benowitz, N; Tyndale, R F
- Abstract
In a placebo-controlled trial, we examined the efficacy of a 6-month ("extended") transdermal nicotine therapy vs. the 8-week ("standard") therapy in 471 Caucasian smokers with either normal or reduced rates of nicotine metabolism as determined at pretreatment. Extended therapy was superior to standard therapy in genotypic or phenotypic reduced metabolizers (RMs) of nicotine but not in normal metabolizers (NMs). RMs of nicotine are candidates for extended transdermal nicotine therapy, whereas an alternative therapeutic approach may be needed for those with normal rates of nicotine metabolism.
- Publication
Clinical pharmacology and therapeutics, 2010, Vol 87, Issue 5, p553
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2010.3