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- Title
Systematic evaluation of drug-disease relationships to identify leads for novel drug uses.
- Authors
Chiang, A P; Butte, A J
- Abstract
Drug repositioning refers to the discovery of alternative uses for drugs--uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could be prospectively tested. We systematically evaluated a drug treatment-based view of diseases in order to address this challenge. Suggestions for novel drug uses were generated using a "guilt by association" approach. When compared with a control group of drug uses, the suggested novel drug uses generated by this approach were significantly enriched with respect to previous and ongoing clinical trials.
- Publication
Clinical pharmacology and therapeutics, 2009, Vol 86, Issue 5, p507
- ISSN
1532-6535
- Publication type
Journal Article
- DOI
10.1038/clpt.2009.103