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- Title
Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.
- Authors
Smith, A R; Visioli, F; Frei, B; Hagen, T M
- Abstract
The age-related decline in vasorelaxation is largely due to ceramide-induced induction of phosphatase 2A (PP2A), which limits nitric oxide synthase (eNOS) phosphorylation at stimulatory sites. We hypothesized that ceramide accumulation was from an age-related loss of endothelial glutathione (GSH) and subsequent activation of neutral sphingomyelinase (nSMase), an enzyme whose activity increases when GSH is limited.
- Publication
British journal of pharmacology, 2008, Vol 153, Issue 8, p1615
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/bjp.2008.28