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- Title
Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms.
- Authors
Xia, L; Wang, X X; Hu, X S; Guo, X G; Shang, Y P; Chen, H J; Zeng, C L; Zhang, F R; Chen, J Z
- Abstract
Recent studies have shown that resveratrol increased endothelial progenitor cells (EPCs) numbers and functional activity. However, the mechanisms remain to be determined. Previous studies have demonstrated that increased EPC numbers and activity were associated with the inhibition of EPC senescence, which involves activation of telomerase. Therefore, we investigated whether resveratrol inhibits the onset of EPC senescence through telomerase activation, leading to potentiation of cellular activity.
- Publication
British journal of pharmacology, 2008, Vol 155, Issue 3, p387
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/bjp.2008.272