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Title
Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation.
Authors
Colucci, R; Blandizzi, C; Ghisu, N; Florio, T; Del Tacca, M
Abstract
Cyclooxygenase-2 (COX-2) is expressed in colonic neoplasms, where it supports cell proliferation via prostaglandin E(2) (PGE(2)) production. This study investigated the effects of somatostatin-14 on COX-2 expression, PGE(2) production and proliferation in colon cancer cells.
Publication
British journal of pharmacology, 2008, Vol 155, Issue 2, p198