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- Title
Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model.
- Authors
Yao, X; Anderson, D L; Ross, S A; Lang, D G; Desai, B Z; Cooper, D C; Wheelan, P; McIntyre, M S; Bergquist, M L; MacKenzie, K I; Becherer, J D; Hashim, M A
- Abstract
Drug-induced prolongation of the QT interval can lead to torsade de pointes, a life-threatening ventricular arrhythmia. Finding appropriate assays from among the plethora of options available to predict reliably this serious adverse effect in humans remains a challenging issue for the discovery and development of drugs. The purpose of the present study was to develop and verify a reliable and relatively simple approach for assessing, during preclinical development, the propensity of drugs to prolong the QT interval in humans.
- Publication
British journal of pharmacology, 2008, Vol 154, Issue 7, p1446
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/bjp.2008.267