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- Title
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
- Authors
Gierten, J; Ficker, E; Bloehs, R; Schlömer, K; Kathöfer, S; Scholz, E; Zitron, E; Kiesecker, C; Bauer, A; Becker, R; Katus, H A; Karle, C A; Thomas, D
- Abstract
Two-pore-domain potassium (K2P) channels mediate potassium background (or 'leak') currents, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Inhibition of K2P currents permits membrane potential depolarization and excitation. As expected for key regulators of excitability, leak channels are under tight control from a plethora of stimuli. Recently, signalling via protein tyrosine kinases (TKs) has been implicated in ion channel modulation. The objective of this study was to investigate TK regulation of K2P channels.
- Publication
British journal of pharmacology, 2008, Vol 154, Issue 8, p1680
- ISSN
0007-1188
- Publication type
Journal Article
- DOI
10.1038/bjp.2008.213