We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human fucosyltransferase 6 enables prostate cancer metastasis to bone.
- Authors
Li, J; Guillebon, A D; Hsu, J-w; Barthel, S R; Dimitroff, C J; Lee, Y-F; King, M R
- Abstract
The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone metastasis in humans. In contrast, the incidence of bone metastasis in mice is rare.
- Publication
British journal of cancer, 2013, Vol 109, Issue 12, p3014
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2013.690