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- Title
Oxidative stress specifically downregulates survivin to promote breast tumour formation.
- Authors
Pervin, S; Tran, L; Urman, R; Braga, M; Parveen, M; Li, S A; Chaudhuri, G; Singh, R
- Abstract
Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, increases aggressive behaviour in ER- breast tumours, oxidative stress (OS) promotes the progression of ER+ breast tumours. Mechanisms and molecular targets by which OS promotes tumourigenesis remain poorly understood.
- Publication
British journal of cancer, 2013, Vol 108, Issue 4, p848
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2013.40