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- Title
Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222.
- Authors
Enciso-Mora, V; Hosking, F J; Di Stefano, A L; Zelenika, D; Shete, S; Broderick, P; Idbaih, A; Delattre, J-Y; Hoang-Xuan, K; Marie, Y; Labussière, M; Alentorn, A; Ciccarino, P; Rossetto, M; Armstrong, G; Liu, Y; Gousias, K; Schramm, J; Lau, C; Hepworth, S J; Schoemaker, M; Strauch, K; Müller-Nurasyid, M; Schreiber, S; Franke, A; Moebus, S; Eisele, L; Swerdlow, A; Simon, M; Bondy, M; Lathrop, M; Sanson, M; Houlston, R S
- Abstract
Most of the heritable risk of glioma is presently unaccounted for by mutations in known genes. In addition to rare inactivating germline mutations in TP53 causing glioma in the context of the Li-Fraumeni syndrome, polymorphic variation in TP53 may also contribute to the risk of developing glioma.
- Publication
British journal of cancer, 2013, Vol 108, Issue 10, p2178
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2013.155