We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.
- Authors
Abkevich, V; Timms, K M; Hennessy, B T; Potter, J; Carey, M S; Meyer, L A; Smith-McCune, K; Broaddus, R; Lu, K H; Chen, J; Tran, T V; Williams, D; Iliev, D; Jammulapati, S; FitzGerald, L M; Krivak, T; DeLoia, J A; Gutin, A; Mills, G B; Lanchbury, J S
- Abstract
Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genomic patterns of loss of heterozygosity (LOH).
- Publication
British journal of cancer, 2012, Vol 107, Issue 10, p1776
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2012.451