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- Title
Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.
- Authors
Greystoke, A; Dean, E; Saunders, M P; Cummings, J; Hughes, A; Ranson, M; Dive, C; Renehan, A G
- Abstract
Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their utility in colorectal cancer (CRC).
- Publication
British journal of cancer, 2012, Vol 107, Issue 9, p1518
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2012.416