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- Title
A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer.
- Authors
Chiappori, A A; Schreeder, M T; Moezi, M M; Stephenson, J J; Blakely, J; Salgia, R; Chu, Q S; Ross, H J; Subramaniam, D S; Schnyder, J; Berger, M S
- Abstract
Bcl-2 family genes are frequently amplified in small cell lung cancer (SCLC). A phase I trial was conducted to evaluate the safety of obatoclax, a Bcl-2 family inhibitor, given in combination with standard chemotherapy.
- Publication
British journal of cancer, 2012, Vol 106, Issue 5, p839
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2012.21