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- Title
The utility of molecular diagnostics to predict recurrence of head and neck carcinoma.
- Authors
Pena Murillo, C; Huang, X; Hills, A; McGurk, M; Lyons, A; Jeannon, J-P; Odell, E; Brown, A; Lavery, K; Barrett, W; Sherriff, M; Brakenhoff, R; Partridge, M
- Abstract
Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.
- Publication
British journal of cancer, 2012, Vol 107, Issue 7, p1138
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2012.213