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- Title
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
- Authors
Tanikawa, M; Wada-Hiraike, O; Nakagawa, S; Shirane, A; Hiraike, H; Koyama, S; Miyamoto, Y; Sone, K; Tsuruga, T; Nagasaka, K; Matsumoto, Y; Ikeda, Y; Shoji, K; Oda, K; Fukuhara, H; Nakagawa, K; Kato, S; Yano, T; Taketani, Y
- Abstract
The TFII-I is a multifunctional transcriptional factor known to bind specifically to several DNA sequence elements and to mediate growth factor signalling. A microdeletion at the chromosomal location 7q11.23 encoding TFII-I and the related family of transcription factors may result in the onset of Williams-Beuren syndrome, an autosomal dominant genetic disorder characterised by a unique cognitive profile, diabetes, hypertension, anxiety, and craniofacial defects. Hereditary breast and ovarian cancer susceptibility gene product BRCA1 has been shown to serve as a positive regulator of SIRT1 expression by binding to the promoter region of SIRT1, but cross talk between BRCA1 and TFII-I has not been investigated to date.
- Publication
British journal of cancer, 2011, Vol 104, Issue 8, p1349
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.75