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- Title
Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours.
- Authors
Pili, R; Salumbides, B; Zhao, M; Altiok, S; Qian, D; Zwiebel, J; Carducci, M A; Rudek, M A
- Abstract
Preclinical studies suggest that histone deacetylase (HDAC) inhibitors may restore tumour sensitivity to retinoids. The objective of this study was to determine the safety, tolerability, and the pharmacokinetic (PK)/pharmacodynamic (PD) profiles of the HDAC inhibitor entinostat in combination with 13-cis retinoic acid (CRA) in patients with solid tumours.
- Publication
British journal of cancer, 2012, Vol 106, Issue 1, p77
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.527