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- Title
KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients.
- Authors
Knijn, N; Mekenkamp, L J M; Klomp, M; Vink-Börger, M E; Tol, J; Teerenstra, S; Meijer, J W R; Tebar, M; Riemersma, S; van Krieken, J H J M; Punt, C J A; Nagtegaal, I D
- Abstract
KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation analysis is usually performed on primary tumour tissue because metastatic tissue is often not available. However, controversial data are available on the concordance of test results between primary tumours and corresponding metastases. We assessed the concordance of KRAS mutation status in a study of 305 primary colorectal tumours and their corresponding liver metastases.
- Publication
British journal of cancer, 2011, Vol 104, Issue 6, p1020
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.26