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- Title
Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells.
- Authors
Pervin, S; Tran, A; Tran, L; Urman, R; Braga, M; Chaudhuri, G; Singh, R
- Abstract
Mechanisms that increase resistance to apoptosis help promote cellular transformation. Cancer cells have deregulated apoptotic pathways, where increased expression and stability of anti-apoptotic proteins Mcl-1 and Bcl-2 increases resistance to apoptosis. Pathways that increase the stability of proteins in cancer cells remain poorly understood.
- Publication
British journal of cancer, 2011, Vol 105, Issue 3, p428
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.242