We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.
- Authors
Spagnuolo, C; Cerella, C; Russo, M; Chateauvieux, S; Diederich, M; Russo, G L
- Abstract
We recently demonstrated that quercetin, a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals, was able to sensitise leukaemic cells isolated from patients with chronic lymphocytic leukaemia (CLL) when associated with recombinant tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) or anti-CD95. We also showed that quercetin potentiated the effect of fludarabine on resistant B cells from CLL patients. Resistance to therapy in CLL depends on the expression and activity of anti-apoptotic proteins of the Bcl-2 family. Among these, myeloid cell leukaemia-1 (Mcl-1) has been associated with apoptotic resistance in CLL. Therefore, we investigate here whether the sensitising activity of this flavonoid, which leads to increased apoptosis in both cell lines and CLL, could be related to Mcl-1 expression and stability.
- Publication
British journal of cancer, 2011, Vol 105, Issue 2, p221
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.229