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- Title
Upregulation of MAPK pathway is associated with survival in castrate-resistant prostate cancer.
- Authors
Mukherjee, R; McGuinness, D H; McCall, P; Underwood, M A; Seywright, M; Orange, C; Edwards, J
- Abstract
Recent evidence has implicated the MAP kinase (MAPK) pathway with the development of castrate-resistant prostate cancer (CRPC). We have previously reported gene amplification of critical members of this pathway with the development of castrate-resistant disease. In addition, we have shown that rising Raf-1 expression, with the development of CRPC, influences time to biochemical relapse. We therefore sought to further analyse the role of both Raf-1 and its downstream target MAPK in the molecular pathogenesis of CRPC.
- Publication
British journal of cancer, 2011, Vol 104, Issue 12, p1920
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/bjc.2011.163