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- Title
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study.
- Authors
Zhou, Shang-Lin; Chu, Hong-Yuan; Jin, Guo-Zhang; Cui, Jian-Min; Zhen, Xue-Chu
- Abstract
3-Methyl-6-chloro-7,8-hydroxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF83959) have been shown to affect several types of voltage-dependent channels in hippocampal pyramidal neurons. The aim of this study was to determine how modulation of a individual type of the channels by SKF83959 contributes to the overall excitability of CA1 pyramidal neurons during either direct current injections or synaptic activation.
- Publication
Acta pharmacologica Sinica, 2014, Vol 35, Issue 6, p738
- ISSN
1745-7254
- Publication type
Journal Article
- DOI
10.1038/aps.2014.23