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- Title
Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.
- Authors
Garbino, Alejandro; Wehrens, Xander H T
- Abstract
Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma membrane and sarcoplasmic reticulum at a fixed distance within the JMC, which is essential for proper Ca(2+)-induced Ca(2+) release during the excitation-contraction process. Recent studies have revealed that mutations in the JPH2 gene are associated with hypertrophic cardiomyopathy, highlighting the importance of this protein for normal cardiac physiology. In this paper, we review current knowledge about the structure and function of junctophilin-2 in the heart.
- Publication
Acta pharmacologica Sinica, 2010, Vol 31, Issue 9, p1019
- ISSN
1745-7254
- Publication type
Journal Article
- DOI
10.1038/aps.2010.116