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- Title
The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats.
- Authors
Senanayake, Gamarallage V K; Banigesh, Ali; Wu, Lingyun; Lee, Paul; Juurlink, Bernhard H J
- Abstract
Our previous studies have shown that broccoli sprouts high in the glucosinolate glucoraphanin decreases renal and vascular oxidative stress and inflammation as well as blood pressure in spontaneously hypertensive stroke-prone (SHRSP) rats. The objective of this study was to determine whether the metabolite of glucoraphanin, sulforaphane, was responsible for this improved blood pressure and whether this is associated with normalization of renal methylated DNA.
- Publication
American journal of hypertension, 2012, Vol 25, Issue 2, p229
- ISSN
1941-7225
- Publication type
Journal Article
- DOI
10.1038/ajh.2011.200